Agmon N, Edelstein A L
Department of Physical Chemistry, Hebrew University, Jerusalem, Israel.
Biophys J. 1995 Mar;68(3):815-25. doi: 10.1016/S0006-3495(95)80258-4.
We investigate the various reactivity patterns possible when several transmitter molecules, released at one side of a synaptic gap, diffuse and bind reversibly to a single receptor at the other end. In the framework of a one-dimensional approximation, the complete time, reactivity, concentration and gap-width dependence are determined, using a rigorous theoretical and computational approach to the many-body aspects of this problem. The time dependence of the survival probability is found to consist of up to four phases. These include a short delay followed by gaussian, power-law, and exponential decay phases. A rigorous expression is derived for the long-time exponent and approximate expressions are obtained for describing the short-time gaussian phase.
我们研究了几种递质分子从突触间隙一侧释放后，扩散并可逆地结合到另一端单个受体时可能出现的各种反应模式。在一维近似框架下，采用严格的理论和计算方法处理该问题的多体方面，确定了完整的时间、反应性、浓度和间隙宽度依赖性。发现存活概率的时间依赖性由多达四个阶段组成。这些阶段包括一个短延迟，随后是高斯、幂律和指数衰减阶段。推导了长时间指数的严格表达式，并获得了描述短时间高斯阶段的近似表达式。
