Friboulet A, Thomas D
Laboratoire de Technologie Enzymatique, URA 1442 du CNRS, Université de Technologie de Compiègne-BP 649, France.
J Theor Biol. 1993 Feb 21;160(4):441-55. doi: 10.1006/jtbi.1993.1029.
An approach derived from reaction-diffusion problems is introduced to describe the synaptic endplate current (EPC) at the neuromuscular junction. The model constructed borrows heavily from earlier models, but it takes into account the anisotropic distribution of the different elements participating to the generation of EPC. The transmitter acetylcholine (ACh) is released at the presynaptic membrane, diffuses through the cleft where acetylcholinesterase is homogeneously distributed and then reaches the postsynaptic surface where the receptor is located. The system is defined by a series of partial differential equations which are solved by an explicit difference method. The model predicts amplitudes and time constants in agreement with those observed experimentally, in all the conditions of inhibition of the enzyme or the receptor tested.
引入一种源自反应扩散问题的方法来描述神经肌肉接头处的突触终板电流（EPC）。构建的模型大量借鉴了早期模型，但考虑到了参与EPC产生的不同元素的各向异性分布。神经递质乙酰胆碱（ACh）在突触前膜释放，通过乙酰胆碱酯酶均匀分布的裂隙扩散，然后到达受体所在的突触后表面。该系统由一系列偏微分方程定义，通过显式差分法求解。在测试的所有酶或受体抑制条件下，该模型预测的幅度和时间常数与实验观察结果一致。
