Lucas A D, Gee S J, Hammock B D, Seiber J N
University of California, Department of Entomology, Davis 95616, USA.
J AOAC Int. 1995 May-Jun;78(3):585-91.
The growing volume of literature concerning immunoassay analysis for trace levels of agrochemicals and other low molecular weight contaminants in various matrixes is indicative of the tremendous interest in and utility of this analytical technique. Most immunoassay methods described in the literature analyze compounds directly, for example, a herbicide in water, or involve solvent exchange of an organic sample extract or dilution of an aqueous-based sample to minimize the matrix effect. As immunoassay for small molecules becomes widely accepted and applied, new challenges involving more complex chemicals in more difficult matrixes arise. The integration of "classical" analytical chemistry with immunochemistry can provide new techniques and approaches useful in discovering the movement, mode of action, and ultimate impact of certain chemicals on humans and the environment.
关于免疫分析技术用于分析各种基质中痕量农用化学品和其他低分子量污染物的文献数量不断增加，这表明人们对该分析技术有着极大的兴趣且其具有实用性。文献中描述的大多数免疫分析方法都是直接分析化合物，例如水中的除草剂，或者涉及有机样品提取物的溶剂交换或水基样品的稀释，以尽量减少基质效应。随着小分子免疫分析方法被广泛接受和应用，在更复杂的基质中分析更复杂化学品的新挑战也随之出现。“经典”分析化学与免疫化学的结合可以提供新的技术和方法，有助于发现某些化学品对人类和环境的迁移、作用方式及最终影响。
