B细胞同种异体抗原的遗传控制：与HLA - A基因座连锁的基因的证据。

Genetic control of B-cell alloantigens: evidence for gene(s) linked to the HLA-A locus.

作者信息

Abelson L D, Mann D L

出版信息

Tissue Antigens. 1978 Mar;11(3):295-301. doi: 10.1111/j.1399-0039.1978.tb01261.x.

DOI:10.1111/j.1399-0039.1978.tb01261.x

Abstract

Families with known HLA recombinant individuals were typed for B-lymphocyte alloantigens. The B-cell alloantigens were found to be inherited with the intact HLA haplotypes. However, the results of the typing of the recombinant individuals indicated that specific antigens are associated with the HLA-A locus and/or with the HLA-B locus. These studies indicate that more than one gene initiates the expression of these antigens and that some of these genes may map between the HLA-A and HLA-B loci.

摘要

对已知有HLA重组个体的家庭进行了B淋巴细胞同种异体抗原分型。发现B细胞同种异体抗原与完整的HLA单倍型一起遗传。然而，重组个体的分型结果表明，特定抗原与HLA - A位点和/或HLA - B位点相关。这些研究表明，不止一个基因启动这些抗原的表达，并且其中一些基因可能定位在HLA - A和HLA - B位点之间。