人类B细胞同种异体抗原的多态性：HLA系统内三个基因座的证据。
Polymorphism of human B-cell alloantigens: evidence for three loci within the HLA system.
作者信息
Markert M L, Cresswell P
出版信息
Proc Natl Acad Sci U S A. 1980 Oct;77(10):6101-4. doi: 10.1073/pnas.77.10.6101.
The B-cell alloantigens of an HLA-DR3-homozygous, MB2-homozygous, MT2-positive lymphoblastoid cell line were studied by two-dimensional gel electrophoresis. Analysis of gel patterns suggested assignment of the HLA-DR3 determinant to the larger (35,000-dalton) subunit (alpha) of the B-cell alloantigen. MB2 was found to be either a determinant on the small (27,000 dalton) subunit (beta) or a crossreactive determinant(s) on the HLA-DR3 alpha subunit and an additional alpha subunit. MT2 was found to be a determinant on Ia antigen-like molecules distinct from those carrying the MB and HLA-DR determinants. The results are consistent with the existence in the major histocompatibility complex of at least three loci encoding B-cell alloantigens.
通过二维凝胶电泳研究了一株 HLA - DR3 纯合、MB2 纯合、MT2 阳性的淋巴母细胞系的 B 细胞同种异体抗原。凝胶图谱分析表明，HLA - DR3 决定簇定位于 B 细胞同种异体抗原的较大（35,000 道尔顿）亚基（α）上。发现 MB2 要么是小（27,000 道尔顿）亚基（β）上的一个决定簇，要么是 HLA - DR3 α 亚基和另一个 α 亚基上的交叉反应决定簇。发现 MT2 是 Ia 抗原样分子上的一个决定簇，与携带 MB 和 HLA - DR 决定簇的分子不同。这些结果与主要组织相容性复合体中至少三个编码 B 细胞同种异体抗原的基因座的存在是一致的。
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