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辐射损伤时血浆核酸含量及组分的变化。辐射防护剂的作用

[Changes in the content and fractional composition of blood plasma nucleic acids in radiation lesions. The effect of radioprotectors].

作者信息

Sherlina S S, Belokhvostov A S, Lebedev S N, Antushevich A E

出版信息

Radiats Biol Radioecol. 1995 Mar-Apr;35(2):244-9.

PMID:7757187
Abstract

The content of DNA in blood plasma increased in early stages after irradiation (2 and 5 h), the low-molecular DNA (160-180 bp) being revealed as opposed to intact animals. Protection of gamma-irradiated rats by cystamine or gammaphos enhanced this phenomenon. The injections of cystamine and gammaphos to nonirradiated animals stimulated DNA ejection into blood stream in 2 h only with normalization by 5 h. Cystamine was the most effective, and in experiment with non-irradiated animals the low-molecular DNA was detected for cystamine only.

摘要

照射后早期(2小时和5小时)血浆中DNA含量增加,与未受照射的动物相比,发现了低分子DNA(160 - 180碱基对)。胱胺或γ-磷对γ射线照射的大鼠的保护作用增强了这一现象。仅在2小时内,向未受照射的动物注射胱胺和γ-磷会刺激DNA进入血流,并在5小时恢复正常。胱胺最为有效,在未受照射动物的实验中,仅胱胺组检测到了低分子DNA。

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