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[辐射损伤中核酸血清组分的变化。大鼠γ射线照射后早期的改变]

[Changes in the serum fraction composition of nucleic acids in radiation injuries. Alterations in an early period after gamma-irradiation of rats].

作者信息

Belokhvostov A S, Lebedev S N, Sherlina S S

出版信息

Radiobiologiia. 1987 Jul-Aug;27(4):505-10.

PMID:2442792
Abstract

The content and fractional composition of nucleic acids of blood serum change after lethal (8 Gy) particularly superlethal (100 Gy) gamma-irradiation of rats. This concerns DNA the content of which increases by 7 times 5 h following 100 Gy irradiation. It has been shown by electrophoresis in 0.85% agarose that a heterogeneous DNA fraction with the molecular weight of (1-15) X 10(6) dalton increases. The analysis of the preparation in the polyacrylamide gel has revealed a DNA fraction that is not found in norm: the fraction possesses the electrophoretic mobility corresponding to that of nucleosome DNA.

摘要

在对大鼠进行致死剂量(8 Gy)尤其是超致死剂量(100 Gy)的γ射线照射后,血清中核酸的含量和分数组成会发生变化。这与DNA有关,在100 Gy照射后5小时,其含量增加了7倍。通过在0.85%琼脂糖中进行电泳表明,分子量为(1 - 15)×10⁶道尔顿的异质DNA组分增加。在聚丙烯酰胺凝胶中对该制剂的分析揭示了一种在正常情况下未发现的DNA组分:该组分具有与核小体DNA相对应的电泳迁移率。

相似文献

1
[Changes in the serum fraction composition of nucleic acids in radiation injuries. Alterations in an early period after gamma-irradiation of rats].[辐射损伤中核酸血清组分的变化。大鼠γ射线照射后早期的改变]
Radiobiologiia. 1987 Jul-Aug;27(4):505-10.
2
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RNA and DNA changes in the bone marrow and blood of rats after neutron and continuous gamma irradiation.中子和连续伽马辐射后大鼠骨髓和血液中的RNA和DNA变化
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Radiation effects on testes. X. Studies on inorganic pyrophosphatase and pyrophosphate following gamma irradiation of rats.辐射对睾丸的影响。十、大鼠γ射线照射后无机焦磷酸酶和焦磷酸的研究。
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[Change in the level of beta 2 microglobulin in the blood of rats in the early period following gamma irradiation].[γ射线照射后早期大鼠血液中β2微球蛋白水平的变化]
Radiobiologiia. 1989 Sep-Oct;29(5):704-5.
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[Effect of tritium oxide in a wide range of doses on the nucleic acid metabolism of the rat spleen].[不同剂量氧化氚对大鼠脾脏核酸代谢的影响]
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A new biodosimetric method: branched DNA-based quantitative detection of B1 DNA in mouse plasma.
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