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[利用单克隆抗体对电离辐射对小鼠胸腺非淋巴样结构影响的免疫形态学研究]

[An immunomorphological study of the effect of ionizing radiation on the nonlymphoid structures of the mouse thymus using monoclonal antibodies].

作者信息

Kuz'menok O I, Beletskaia L V, Gnezditskaia E V, Iarilin A A

出版信息

Radiats Biol Radioecol. 1995 Mar-Apr;35(2):255-9.

PMID:7757189
Abstract

Expression of cytoskeleton components revealed with monoclonal antibodies was increased in epithelial cells of mouse thymus one day after total gamma-irradiation with doses of 0.5-4.0 Gy, while after the doses of 10 and 15 Gy it was decreased. The antigen expression was reversed to initial level 14 days after the dose of 4 Gy; thymocyte depletion was progressed and continuous massifs of epithelial cells was formed. The oval cysts and immunoglobulin deposits were appeared in thymus two months after irradiation with the dose of 4 Gy.

摘要

用单克隆抗体检测发现,在0.5 - 4.0 Gy剂量的全身γ射线照射后1天,小鼠胸腺上皮细胞中细胞骨架成分的表达增加,而在10和15 Gy剂量照射后表达下降。4 Gy剂量照射14天后,抗原表达恢复到初始水平;胸腺细胞耗竭进展,形成连续的上皮细胞团块。4 Gy剂量照射两个月后,胸腺中出现椭圆形囊肿和免疫球蛋白沉积。

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