Kuz'menok O I, Beletskaia L V, Gnezditskaia E V, Iarilin A A
Radiats Biol Radioecol. 1995 Mar-Apr;35(2):255-9.
Expression of cytoskeleton components revealed with monoclonal antibodies was increased in epithelial cells of mouse thymus one day after total gamma-irradiation with doses of 0.5-4.0 Gy, while after the doses of 10 and 15 Gy it was decreased. The antigen expression was reversed to initial level 14 days after the dose of 4 Gy; thymocyte depletion was progressed and continuous massifs of epithelial cells was formed. The oval cysts and immunoglobulin deposits were appeared in thymus two months after irradiation with the dose of 4 Gy.
用单克隆抗体检测发现，在0.5 - 4.0 Gy剂量的全身γ射线照射后1天，小鼠胸腺上皮细胞中细胞骨架成分的表达增加，而在10和15 Gy剂量照射后表达下降。4 Gy剂量照射14天后，抗原表达恢复到初始水平；胸腺细胞耗竭进展，形成连续的上皮细胞团块。4 Gy剂量照射两个月后，胸腺中出现椭圆形囊肿和免疫球蛋白沉积。
