Kuzmenok O I, Beliakov I M, Iarilin A A, Arshinov V Iu
Radiats Biol Radioecol. 1993 Jul-Aug;33(4):549-56.
In 3- and 9-month experiments with mice, a study was made of the effect of radiation on serum alpha 1-thymosine concentration after whole-body irradiation and local exposure of the thymus at doses of 1-20 Gy. The effect of 137Cs-gamma-rays on the in vitro cultured thymus stroma cells, with respect to alpha 1-thymosine secretion, and the influence of local irradiation of the thymus of production of autoantibodies that react with epithelial thymus cells were studied. Both whole-body irradiation and local exposure of the thymus were shown to cause changes in the alpha 1-thymosine content of the blood plasma. The direction and dynamics of the changes observed are different with whole-body and local exposure. Irradiation of cultured thymus cells of mice causes alterations in alpha 1-thymosine secretion, that is, stimulation at a dose of 1 Gy and inhibition at higher doses. With respect to dose- and time-response, these changes are closer to those observed in alpha 1-thymosine concentration in mouse serum after whole-body irradiation than after local exposure of the thymus in vivo. At remote times after local irradiation of the thymus with doses of 1-10 Gy, autoantibodies are found in mouse serum that react with epithelial cells of the thymus stroma. Autoantibodies are absent at doses of 15 and 20 Gy.
在对小鼠进行的为期3个月和9个月的实验中，研究了全身照射以及以1 - 20戈瑞的剂量局部照射胸腺后，辐射对血清α1 - 胸腺素浓度的影响。研究了137Cs - γ射线对体外培养的胸腺基质细胞α1 - 胸腺素分泌的影响，以及胸腺局部照射对与胸腺上皮细胞发生反应的自身抗体产生的影响。全身照射和胸腺局部照射均显示会导致血浆中α1 - 胸腺素含量发生变化。全身照射和局部照射所观察到的变化方向和动态有所不同。照射小鼠培养的胸腺细胞会导致α1 - 胸腺素分泌发生改变，即1戈瑞剂量时受到刺激，更高剂量时受到抑制。在剂量 - 时间反应方面，这些变化与全身照射后小鼠血清中α1 - 胸腺素浓度的变化比与体内胸腺局部照射后的变化更为接近。在以1 - 10戈瑞剂量局部照射胸腺后的远期，在小鼠血清中发现了与胸腺基质上皮细胞发生反应的自身抗体。在15和20戈瑞剂量时未发现自身抗体。
