Savina N P, Iarilin A A
Radiats Biol Radioecol. 1995 Jul-Aug;35(4):486-93.
Mice were grafted with syngeneic neonatal thymus 1-3 days or 7.5-8 months after local irradiation of thymus, hypothalamus/hypophysis and gonads. Thymus weight and thymocyte number were measured in autologous and grafted thymus 35-40 days after the transplantation. Thymus transplantation induces significant decrease in weight and cellularity of both autologous and grafted thymus. Irradiation of autologous and grafted thymus in doses of 1 and 10 Gy abrogates this effect. Irradiation of hypothalamus/hypophysis and gonads induces decrease of weight and cellularity of autologous and grafted thymus. Irradiation of gonads does not abrogate inhibitory effect of thymus transplantation. Local irradiation of all three regions decreases titre of serum thymic activity and influence concentrations of some hypophysis and adrenal hormones.
在对胸腺、下丘脑/垂体和性腺进行局部照射1 - 3天或7.5 - 8个月后，将同基因新生胸腺移植到小鼠体内。在移植后35 - 40天，测量自体胸腺和移植胸腺的重量及胸腺细胞数量。胸腺移植导致自体胸腺和移植胸腺的重量及细胞数量显著减少。以1 Gy和10 Gy的剂量照射自体胸腺和移植胸腺可消除这种效应。照射下丘脑/垂体和性腺会导致自体胸腺和移植胸腺的重量及细胞数量减少。照射性腺并不能消除胸腺移植的抑制作用。对所有三个区域进行局部照射会降低血清胸腺活性的滴度，并影响一些垂体和肾上腺激素的浓度。
