Berardesca E, Vignoli G P, Distante F, Brizzi P, Rabbiosi G
Department of Dermatology, University of Pavia, IRCCS Policlinico S. Matteo, Italy.
Contact Dermatitis. 1995 Feb;32(2):83-7. doi: 10.1111/j.1600-0536.1995.tb00751.x.
Surfactant-induced irritant reactions may be elicited by several endogenous and exogenous factors. Among these, surfactant concentration, and duration and frequency of exposure play important rôles. The study focuses on the influence of water temperature in determining damage of the skin barrier. 10 subjects of both sexes entered the study. 4 areas (4 x 4 cm2) were randomly selected on the volar forearm and were treated with a daily open application of 5% sodium lauryl sulphate for 4 days. The solutions were at 3 temperatures: 4 degrees, 20 degrees and 40 degrees C. One site served as untreated control. On the 5th day, skin irritation was evaluated using transepidermal water loss (TEWL) measurements, erythema (a* value), skin reflectance (L* value), hydration (capacitance) and desquamation (stripping). The results show a significant effect of the solution's temperature in determining skin irritation (P < 0.001). Skin damage was higher in sites treated with warmer temperatures and a highly significant correlation (P < 0.001) between irritation and temperature was found. In conclusion, the study shows that water temperature during washing has an important effect on the onset of irritant contact dermatitis.
表面活性剂诱导的刺激性反应可能由多种内源性和外源性因素引起。其中，表面活性剂浓度、暴露持续时间和频率起着重要作用。该研究聚焦于水温对皮肤屏障损伤的影响。10名男女受试者参与了该研究。在掌侧前臂随机选取4个区域（4×4平方厘米），每天开放性涂抹5%的十二烷基硫酸钠，持续4天。溶液有3个温度：4摄氏度、20摄氏度和40摄氏度。一个部位作为未处理的对照。在第5天，使用经表皮水分流失（TEWL）测量、红斑（a值）、皮肤反射率（L值）、水合作用（电容）和脱屑（剥离）来评估皮肤刺激性。结果表明溶液温度对确定皮肤刺激性有显著影响（P<0.001）。温度较高的部位皮肤损伤更严重，并且发现刺激性与温度之间存在高度显著的相关性（P<0.001）。总之，该研究表明洗涤过程中的水温对刺激性接触性皮炎的发生有重要影响。
