Ohlenschlaeger J, Friberg J, Ramsing D, Agner T
Department of Dermatology, University of Copenhagen, Gentofte Hospital, Hellerup, Denmark.
Acta Derm Venereol. 1996 Jul;76(4):274-6. doi: 10.2340/0001555576274276.
Exposure to water and detergents is an important factor for development of irritant contact dermatitis. The aim of the present study was to investigate the effect of temperature on the damaging effects of water and detergents on the skin. Twenty healthy volunteers participated in the study. Ten participants had right and left forearms immersed into a detergent (soap) solution for 2 days twice daily for 10 min. Another 10 participants had both forearms immersed into sterile water. Right and left forearms were randomized to immersion into 20 degrees C and 40 degrees C solutions, respectively. Reactions were evaluated clinically, and by measurement of transepidermal water loss, electrical capacitance and erythema. Immersions into 40 degrees C sodium lauryl sulphate solution caused significantly increased transepidermal water loss as compared to immersion into 20 degrees C sodium lauryl sulphate solution. Electrical capacitance and erythema were not significantly influenced by temperature. Immersion into water caused no significant changes in any observed parameter. Water temperature influences the irritant capacity of a detergent. Change of temperature may be a simple but important means for prevention of irritant contact dermatitis.
接触水和洗涤剂是刺激性接触性皮炎发病的一个重要因素。本研究的目的是调查温度对水和洗涤剂对皮肤损伤作用的影响。20名健康志愿者参与了该研究。10名参与者的左右前臂每天两次浸泡在洗涤剂（肥皂）溶液中，每次10分钟，持续2天。另外10名参与者的双侧前臂浸泡在无菌水中。左右前臂分别随机浸泡在20摄氏度和40摄氏度的溶液中。通过临床评估以及测量经表皮水分流失、电容和红斑来评估反应。与浸泡在20摄氏度的月桂醇硫酸酯钠溶液中相比，浸泡在40摄氏度的月桂醇硫酸酯钠溶液中导致经表皮水分流失显著增加。电容和红斑不受温度的显著影响。浸泡在水中未导致任何观察参数出现显著变化。水温会影响洗涤剂的刺激能力。温度变化可能是预防刺激性接触性皮炎的一种简单但重要的方法。
