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三例心肺移植患者的医院获得性军团菌病:病例报告及环境观察

Nosocomial legionellosis in three heart-lung transplant patients: case reports and environmental observations.

作者信息

Bangsborg J M, Uldum S, Jensen J S, Bruun B G

机构信息

Department of Clinical Microbiology, Statens Seruminstitut, Artillerivej, Copenhagen S, Denmark.

出版信息

Eur J Clin Microbiol Infect Dis. 1995 Feb;14(2):99-104. doi: 10.1007/BF02111866.

DOI:10.1007/BF02111866
PMID:7758494
Abstract

Organ transplant recipients are at high risk of contracting Legionnaires' disease in a hospital environment contaminated with legionellae. This study describes the first cases of culture-verified Legionella infections with an established link to potable hospital water in Denmark; three patients operated on at the Cardiopulmonary Transplant Unit, Rigshospitalet, Copenhagen, became infected with legionellae. Environmental and clinical isolates of Legionella pneumophila serogroups 1 and 6 were investigated by restriction enzyme analysis and ribotyping. An ice machine located in the kitchen of the intensive care unit was implicated as a source of infection in two of the three cases.

摘要

在被军团菌污染的医院环境中,器官移植受者感染军团病的风险很高。本研究描述了丹麦首例经培养证实的军团菌感染病例,这些病例与医院的饮用水有明确关联;三名在哥本哈根里格霍斯医院心肺移植科接受手术的患者感染了军团菌。对嗜肺军团菌血清型1和6的环境分离株及临床分离株进行了限制性内切酶分析和核糖体分型研究。在这三例病例中,有两例的感染源被认为是重症监护病房厨房中的一台制冰机。

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Nosocomial legionellosis in three heart-lung transplant patients: case reports and environmental observations.三例心肺移植患者的医院获得性军团菌病:病例报告及环境观察
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2
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本文引用的文献

1
Legionnaires' disease in cardiac transplant patients: a cell-mediated immune response develops despite cyclosporine therapy.
J Infect Dis. 1993 Aug;168(2):521-2. doi: 10.1093/infdis/168.2.521.
2
Nosocomial Legionnaires' disease: aspiration as a primary mode of disease acquisition.医院获得性军团菌病:吸入作为疾病获得的主要方式。
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3
Could aspiration be the major mode of transmission for Legionella?吸入是否可能是军团菌的主要传播方式?
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4
Ribotyping for differentiating Flavobacterium meningosepticum isolates from clinical and environmental sources.用于区分临床和环境来源的脑膜败血金黄杆菌分离株的核糖体分型。
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Legionnaires' disease: the infective dose paradox.军团病:感染剂量悖论。
Lancet. 1993 Jul 3;342(8862):5-6. doi: 10.1016/0140-6736(93)91877-o.
6
Oropharyngeal colonization with Legionella pneumophila.嗜肺军团菌在口咽部的定植。
J Clin Microbiol. 1983 Nov;18(5):1108-12. doi: 10.1128/jcm.18.5.1108-1112.1983.
7
Reactivity of serum from patients with suspected legionellosis against 29 antigens of legionellaceae and Legionella-like organisms by indirect immunofluorescence assay.采用间接免疫荧光法检测疑似军团病患者血清对军团菌科及类军团菌29种抗原的反应性。
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8
Legionnaires' disease related to gastric lavage with tap water.与用自来水洗胃相关的军团病。
Lancet. 1982 Apr 3;1(8275):797-8. doi: 10.1016/s0140-6736(82)91837-2.
9
Nosocomial Legionnaires' disease. Epidemiologic demonstration of cooling towers as a source.医院获得性军团菌病。冷却塔作为传染源的流行病学证明。
JAMA. 1985 Jul 26;254(4):521-4. doi: 10.1001/jama.254.4.521.
10
Isolation of Legionella pneumophila from the cold water of hospital ice machines: implications for origin and transmission of the organism.
Infect Control. 1985 Apr;6(4):141-6. doi: 10.1017/s0195941700062937.