Rosendahl Madsen A M, Holm A, Jensen T G, Knudsen E, Lundgaard H, Skov M N, Uldum S A, Kemp M
Department of Clinical Microbiology, Odense University Hospital, Odense, Denmark.
Department of Clinical Microbiology, Odense University Hospital, Odense, Denmark.
J Hosp Infect. 2017 Aug;96(4):392-395. doi: 10.1016/j.jhin.2017.04.020. Epub 2017 Apr 27.
Acquisition of Legionnaires' disease is a serious complication of hospitalization. Rapid determination of whether or not the infection is caused by strains of Legionella pneumophila in the hospital environment is crucial to avoid further cases. This study investigated the use of whole-genome sequencing to identify the source of infection in hospital-acquired Legionnaires' disease. Phylogenetic analyses showed close relatedness between one patient isolate and a strain found in hospital water, confirming suspicion of nosocomial infection. It was found that whole-genome sequencing can be a useful tool in the investigation of hospital-acquired Legionnaires' disease.
获得军团病是住院治疗的一种严重并发症。快速确定医院环境中的感染是否由嗜肺军团菌菌株引起对于避免更多病例至关重要。本研究调查了使用全基因组测序来确定医院获得性军团病的感染源。系统发育分析表明，一名患者的分离株与医院水中发现的一种菌株密切相关，证实了对医院感染的怀疑。研究发现，全基因组测序可以成为调查医院获得性军团病的有用工具。
