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一项关于以色列丙型肝炎病毒无症状携带者献血者与肝脏疾病、冷球蛋白血症及传播关系的研究。

A study of Israeli blood donors, asymptomatic carriers of hepatitis C virus, in relation to liver disease, cryoglobulinemia and transmission.

作者信息

Stern M, Manny N, Klein A, Naparstek Y, Shraga S, Tur-Kaspa R

机构信息

Division of Medicine, Hadassah University Hospital, Jerusalem, Israel.

出版信息

Isr J Med Sci. 1995 May;31(5):277-9.

PMID:7759221
Abstract

In order to study the asymptomatic hepatitis C virus (HCV)-positive blood donors in Israel we analyzed their sera for HCV-RNA using the polymerase chain reaction technique. We found that 0.44% of blood donors were anti-HCV positive. Of those who had repeatedly positive anti-HCV, 82% had evidence of HCV-RNA. One-third of them had elevated liver enzymes, but no detectable cryoglobulins were found in their sera. Although HCV-RNA was detected in the majority of the patients, we were unable to demonstrate vertical or horizontal transmission among the family members of our carrier population.

摘要

为了研究以色列无症状丙型肝炎病毒(HCV)阳性献血者,我们采用聚合酶链反应技术对他们的血清进行了HCV-RNA分析。我们发现0.44%的献血者抗-HCV呈阳性。在抗-HCV反复呈阳性的人群中,82%有HCV-RNA证据。其中三分之一的人肝酶升高,但血清中未检测到冷球蛋白。尽管在大多数患者中检测到了HCV-RNA,但我们未能证实在我们的携带者人群的家庭成员之间存在垂直或水平传播。

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