Zimlichman R, Zilberman D, Gold B
Department of Medicine, Wolfson Medical Center, Holon, Israel.
Isr J Med Sci. 1995 May;31(5):288-92.
The hemodynamic effects of oral nisoldiopine in 12 hypertensive patients aged 35-55 years were determined using the impedance cardiography method. Hemodynamic measurements were performed at hourly intervals before and following ingestion of the medication. Nisoldipine significantly decreased systolic and diastolic blood pressure, with a slight increase in heart rate. Stroke volume did not change significantly following the medication. Total peripheral resistance decreased gradually reaching its lowest values 2 h after ingestion of nisoldipine. We conclude that nisoldipine is a potent oral antihypertensive agent that induces peripheral vasodilatation without decrease in cardiac output.
采用阻抗心动图法测定了12例年龄在35至55岁之间的高血压患者口服尼索地平后的血流动力学效应。在服药前和服药后每隔一小时进行血流动力学测量。尼索地平显著降低收缩压和舒张压，心率略有增加。服药后每搏输出量无显著变化。总外周阻力逐渐降低，在服用尼索地平后2小时达到最低值。我们得出结论，尼索地平是一种有效的口服抗高血压药物，可诱导外周血管扩张而不降低心输出量。
