Vasseur P B, Johnson A L, Budsberg S C, Lincoln J D, Toombs J P, Whitehair J G, Lentz E L
Department of Surgical and Radiological Science, School of Veterinary Medicine, University of California, Davis 95616, USA.
J Am Vet Med Assoc. 1995 Mar 15;206(6):807-11.
Seventy dogs were included in a randomized, controlled, multicenter trial to test the efficacy of carprofen (2.2 mg/kg of body weight, PO, q 12 h) for relief of clinical signs associated with osteoarthritis. Thirty-six dogs received carprofen, and 34 received a placebo. Response of the dogs was evaluated by comparing results of force plate examination and a graded lameness examination performed before and immediately after 2 weeks of treatment, and by obtaining a subjective assessment of the dog's posttreatment condition from owners and participating veterinarians. A physical examination, CBC, serum biochemical analyses, urinalysis, and fecal occult blood test were performed before and after treatment to monitor safety. For force plate evaluation, the odds ratio was 3.3, meaning that a dog treated with carprofen was 3.3 times more likely to have a positive response than was a dog treated with the placebo. For evaluation by a veterinarian, the odds ratio was 3.5, and for owner evaluation, the odds ratio was 4.2. Institution where dogs were treated did not have a significant effect on results. A variety of reactions that may have been related to the medication (placebo or carprofen) were recorded; however, none were considered serious. Serum alanine aminotransferase activity was high in 3 dogs (2 that received placebo and 1 that received carprofen) at the conclusion of treatment; none of the 3 dogs were clinically ill. Ten dogs (5 that received placebo and 5 that received caprofen) had negative pretreatment and positive posttreatment fecal occult blood test results.
七十只狗被纳入一项随机、对照、多中心试验，以测试卡洛芬（2.2毫克/千克体重，口服，每12小时一次）缓解与骨关节炎相关临床症状的疗效。三十六只狗接受卡洛芬治疗，三十四只接受安慰剂治疗。通过比较治疗前和治疗2周后立即进行的测力板检查和分级跛行检查结果，并从狗主人和参与的兽医那里获得对狗治疗后状况的主观评估，来评估狗的反应。治疗前后进行体格检查、血常规、血清生化分析、尿液分析和粪便潜血试验以监测安全性。对于测力板评估，优势比为3.3，这意味着接受卡洛芬治疗的狗产生阳性反应的可能性是接受安慰剂治疗的狗的3.3倍。对于兽医评估，优势比为3.5，对于主人评估，优势比为4.2。治疗狗的机构对结果没有显著影响。记录了各种可能与药物（安慰剂或卡洛芬）有关的反应；然而，没有一种被认为是严重的。治疗结束时，3只狗（2只接受安慰剂，1只接受卡洛芬）的血清丙氨酸转氨酶活性较高；这3只狗均无临床疾病。十只狗（5只接受安慰剂，5只接受卡洛芬）治疗前粪便潜血试验结果为阴性，治疗后为阳性。
