Leevy C M, Zetterman R K
Am Fam Physician. 1976 Jun;13(6):60-7.
Alcoholic hepatitis is the precursor of cirrhosis. Susceptibility is independent of amount and duration of ethanol intake or of diet. Centrilobular hyalin, the key morphologic abnormality, sensitizes lymphocytes to secrete factors which may account (in part) for necrosis, liver cell destruction, increased collagen synthesis and development of cirrhosis. Diagnosis may be facilitated by detection of alcoholic hyalin antigen (AHAg) and antibody (AHAb) in serum of patients with alcoholic hepatitis. Treatment requires abstinence. Steroids have not reduced mortality rates. Measures to improve immunologic reactivity may be helpful. Persons unable to abstain should be enrolled in a surveillance group.
酒精性肝炎是肝硬化的前驱病变。易感性与乙醇摄入量、摄入持续时间或饮食无关。中央静脉周围透明变性是关键的形态学异常，它使淋巴细胞致敏以分泌可能（部分）导致坏死、肝细胞破坏、胶原合成增加及肝硬化发展的因子。检测酒精性肝炎患者血清中的酒精性透明抗原（AHAg）和抗体（AHAb）有助于诊断。治疗需要戒酒。类固醇并未降低死亡率。改善免疫反应性的措施可能会有帮助。无法戒酒的人应纳入监测组。
