Zetterman R K, Luisada-Opper A, Leevy C M
Gastroenterology. 1976 Mar;70(3):382-4.
Immunological reactivity in alcoholic hepatitis has bben attributed to alcoholic hyalin, the histological hallmark of this disease. A purified isolate of alcoholic hyalin with electron microscopic, biochemical, and serological characteristics documented previously was added to lymphocytes from healthy subjects and patients with alcoholic hepatitis or other hepatic disorders. Production of migration inhibition factor (MIF) in response to this material was used as an index to lymphocyte reactivity. MIF was significantly increased in lymphocytes obtained from patients with alcoholic hepatis, as compared to the healthy controls (P less than 0.001), and persons with other liver diseases (P less than 0.005). These observations indicate that immunological hyperreactivity to alcoholic hyalin occurs in patients with alcoholic hepatitis; such activity may be of key importance in the pathogenesis or sequelae (or both) of this disease.
酒精性肝炎中的免疫反应性一直被归因于酒精透明小体，它是这种疾病的组织学标志。将先前记录的具有电子显微镜、生化和血清学特征的纯化酒精透明小体分离物添加到健康受试者以及患有酒精性肝炎或其他肝脏疾病的患者的淋巴细胞中。将对该物质产生的迁移抑制因子（MIF）用作淋巴细胞反应性的指标。与健康对照组（P<0.001）和患有其他肝脏疾病的人（P<0.005）相比，酒精性肝炎患者的淋巴细胞中MIF显著增加。这些观察结果表明，酒精性肝炎患者对酒精透明小体存在免疫反应亢进；这种活性可能在该疾病的发病机制或后遗症（或两者）中起关键作用。
