Weiss M, Birkhahn A, Mettler S, Schneider M, Wernet P
Department of Anesthesiology, Heinrich-Heine-Universität, Düsseldorf, Germany.
Immunopharmacol Immunotoxicol. 1995 Feb;17(1):91-107. doi: 10.3109/08923979509052723.
The effects of the commercially available ketamine preparation (Ketanest), the ketamine racemate and of the two enantiomers, the R(-)-racemate and the S(+)-racemate, as well as its drug-free solvent were examined by N-formyl-methionyl-leucyl-phenylalanine-(FMLP)- and zymosan-induced oxygen radical production of polymorphonuclear cells (PMN). The racemate and the two enantiomers of ketamine suppressed FMLP- and zymosan-induced chemiluminescence of PMN in a dose-dependent fashion to the same extent. Therefore suppression of chemiluminescence of PMN by ketamine does not result from a specific receptor interaction.
通过N-甲酰甲硫氨酰-亮氨酰-苯丙氨酸（FMLP）和酵母聚糖诱导的多形核细胞（PMN）氧自由基生成，研究了市售氯胺酮制剂（凯他敏）、氯胺酮消旋体及其两种对映体R（-）-对映体和S（+）-对映体以及其无药溶剂的作用。氯胺酮消旋体及其两种对映体以剂量依赖方式同等程度地抑制了FMLP和酵母聚糖诱导的PMN化学发光。因此，氯胺酮对PMN化学发光的抑制并非源于特异性受体相互作用。
