HLA - B基因座存在独特的高水平重组。
A uniquely high level of recombination at the HLA-B locus.
作者信息
McAdam S N, Boyson J E, Liu X, Garber T L, Hughes A L, Bontrop R E, Watkins D I
机构信息
Wisconsin Regional Primate Research Center, University of Wisconsin, Madison 53715.
出版信息
Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):5893-7. doi: 10.1073/pnas.91.13.5893.
Abstract
Major histocompatibility complex (MHC) loci are some of the most polymorphic genes in the animal kingdom. Recently, it has been suggested that although most of the human MHC loci are relatively stable, the HLA-B locus can undergo rapid changes, especially in isolated populations. To investigate the mechanisms of HLA-B evolution we have compared the sequences of 19 HLA-B homologues from chimpanzees and bonobos to 65 HLA-B sequences. Analysis of the chimpanzee and bonobo HLA-B homologues revealed that despite obvious similarities between chimpanzee and human alleles in exon 2, there was little conservation of exon 3 between humans and the two chimpanzee species. This finding suggests that, unlike all other HLA loci, recombination has characterized the HLA-B locus and its homologues for over 5 million years.
摘要
主要组织相容性复合体（MHC）基因座是动物界中多态性最高的一些基因。最近，有人提出，尽管大多数人类MHC基因座相对稳定，但HLA - B基因座可能会发生快速变化，尤其是在孤立人群中。为了研究HLA - B进化的机制，我们将来自黑猩猩和倭黑猩猩的19个HLA - B同源序列与65个HLA - B序列进行了比较。对黑猩猩和倭黑猩猩HLA - B同源序列的分析表明，尽管黑猩猩和人类等位基因在第2外显子上有明显相似性，但人类与这两种黑猩猩物种在第3外显子上几乎没有保守性。这一发现表明，与所有其他HLA基因座不同，重组在超过500万年的时间里一直是HLA - B基因座及其同源序列的特征。
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