Romagnani S, Del Prete G, Maggi E, Chilosi M, Caligaris-Cappio F, Pizzolo G
Istituto di Clinica Medica 3, University of Florence, Italy.
J Leukoc Biol. 1995 May;57(5):726-30. doi: 10.1002/jlb.57.5.726.
CD30 is one of the members of the tumor necrosis factor receptor superfamily, originally described as a marker of Reed-Sternberg and Hodgkin's cells in Hodgkin's lymphoma. CD30 appears to be preferentially expressed on, and its soluble form (sCD30) released by, CD4+ and CD8+ T cell clones capable of producing T helper 2 (Th2)-type cytokines. In noneoplastic conditions, CD30+ T cells are barely detectable in vivo; however, a few allergen-specific CD4+CD30+ T cells inducible to the production of Th2-type cytokines could be sorted out from the circulation of allergic subjects after allergen exposure. Moreover, high numbers of CD30+ T cells were found in the lymph node of a patient suffering from Omenn's syndrome, a rare congenital Th2-mediated immunodeficiency disorder. More importantly, high serum levels of sCD30 were observed in some conditions in which a pathogenetic role for Th2 cells has been suggested, such as Omenn's syndrome, atopy, systemic lupus erythematosus, and after infection with measles virus or human immunodeficiency virus. Thus, detection of CD30+ T cells and/or of increased levels of sCD30 may reflect the presence of immune responses or immune alterations characterized by the prevalent activation of Th2-like cells.
CD30是肿瘤坏死因子受体超家族的成员之一，最初被描述为霍奇金淋巴瘤中里德-斯腾伯格细胞和霍奇金细胞的标志物。CD30似乎优先表达于能够产生辅助性T细胞2（Th2）型细胞因子的CD4+和CD8+T细胞克隆上，并由其释放可溶性形式（sCD30）。在非肿瘤性情况下，体内几乎检测不到CD30+T细胞；然而，在变应原暴露后，可从变应性受试者的循环中筛选出少数可诱导产生Th2型细胞因子的变应原特异性CD4+CD30+T细胞。此外，在一名患有奥门综合征（一种罕见的先天性Th2介导的免疫缺陷疾病）的患者的淋巴结中发现了大量CD30+T细胞。更重要的是，在一些提示Th2细胞具有致病作用的情况下，如奥门综合征、特应性、系统性红斑狼疮以及感染麻疹病毒或人类免疫缺陷病毒后，观察到血清sCD30水平升高。因此，检测CD30+T细胞和/或sCD30水平升高可能反映了以Th2样细胞普遍激活为特征的免疫反应或免疫改变的存在。
