Eksantivongs S, Poungvarin N, Viriyavejakul A, Punyamee J
Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
J Med Assoc Thai. 1994 Dec;77(12):627-32.
Twenty patients with primary hemifacial spasm and ten patients with Parkinson's disease were studied by means of paired stimuli blink reflex. The second stimuli were delivered at a varying time interval between 50-900 ms. The R2 response's absolute refractory periods were compared between patients and twenty one age-matched normal controls as well as between hemifacial spasm and Parkinson's disease. In normal subjects, the mean absolute refractory period was found to be 271.42 +/- 64.36 ms, in hemifacial spasm 160.00 +/- 50.62 ms and in Parkinson's disease 157.14 +/- 53.45 ms. The absolute refractory periods obtained from patients were significantly shorter than in normal controls (p < 0.05). However the values between patients with hemifacial spasm and Parkinson's disease were not (p > 0.05). This result strongly supports bilateral facial motoneurons hyperexcitability as the underlying mechanism of hemifacial spasm.
采用配对刺激眨眼反射对20例原发性面肌痉挛患者和10例帕金森病患者进行了研究。第二个刺激在50 - 900毫秒的不同时间间隔下施加。比较了患者与21名年龄匹配的正常对照之间以及面肌痉挛和帕金森病患者之间R2反应的绝对不应期。在正常受试者中，平均绝对不应期为271.42±64.36毫秒，面肌痉挛患者为160.00±50.62毫秒，帕金森病患者为157.14±53.45毫秒。患者的绝对不应期明显短于正常对照（p < 0.05）。然而，面肌痉挛患者和帕金森病患者之间的值没有差异（p > 0.05）。这一结果有力地支持了双侧面部运动神经元兴奋性过高是面肌痉挛的潜在机制。
