Heptinstall R H
Am J Pathol. 1976 Apr;83(1):213-36.
Interstitial nephritis is a common condition, which in spite of a relatively constant pathologic picture has different etiologic agents and pathogenetic mechanisms. Failure to appreciate this, particularly in the chronic group, has led to considerable confusion and has been largely responsible for the overdiagnosis of chronic pyelonephritis. Although we are still largely ignorant of the causes of interstitial nephritis, it is now possible to define many of them. While experimental studies have not made spectacular contributions to our understanding, an attempt is now being made to develop appropriate models, and we hope these will enable us to still further clarify our understanding of other entities.
间质性肾炎是一种常见疾病,尽管其病理表现相对恒定,但病因和发病机制却各不相同。未能认识到这一点,尤其是在慢性病例中,导致了相当大的混乱,并且在很大程度上造成了慢性肾盂肾炎的过度诊断。虽然我们对间质性肾炎的病因仍知之甚少,但现在已经能够明确其中的许多病因。尽管实验研究尚未对我们的理解做出显著贡献,但目前正在尝试建立合适的模型,我们希望这些模型将使我们能够进一步阐明对其他疾病实体的理解。