新虹吸菌素A，一种新型环缩肽，具有来自海洋海绵超新虹吸菌的抗真菌活性。

Neosiphoniamolide A, a novel cyclodepsipeptide, with antifungal activity from the marine sponge Neosiphonia superstes.

作者信息

D'Auria M V, Gomez Paloma L, Minale L, Zampella A, Debitus C, Perez J

机构信息

Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Italy.

出版信息

J Nat Prod. 1995 Jan;58(1):121-3. doi: 10.1021/np50115a017.

DOI:10.1021/np50115a017

PMID:7760068

Abstract

A novel cyclodepsipeptide, neosiphoniamolide A [1], has been isolated from the sponge Neosiphonia superstes. The structure of 1, which contains a 12-carbon hydroxy acid, glycine, valine, and a halogenated tyrosine residue in an 18-membered ring, is related to jaspamide and the geodiamolides, previously isolated from sponges. The structure was solved by spectroscopic analysis.

摘要

从海绵新管海绵（Neosiphonia superstes）中分离出一种新型环缩肽，新管海绵内酯A [1]。化合物1的结构包含一个12碳的羟基酸、甘氨酸、缬氨酸以及一个位于18元环中的卤代酪氨酸残基，其结构与之前从海绵中分离出的茉莉酰胺和地二酰胺有关。该结构通过光谱分析得以解析。