Farman U, Wang D X, Deng J
Department of Pathophysiology, Tongji Medical University, Wuhan.
J Tongji Med Univ. 1994;14(4):252-6. doi: 10.1007/BF02897681.
The effects of 3,4-DHAP on hypoxic vasoconstriction response in pulmonary (PA) and basilar arterial (BA) rings of rabbits and their mechanism were compared in vitro. 3,4-DHAP in different concentration (2.64 x 10(-4), 7.92 x 10(-4), 2.376 x 10(-3) mol/L) decreased the basal tone of PA rings by 32.39 +/- 9.4 mg, 68.96 +/- 26.54 mg and 145.60 +/- 58.07 mg respectively, while the tension of the BA rings was decreased by 13.80 +/- 5.08 mg, 17.18 +/- 3.36 mg and 25.00 +/- 4.02 mg respectively. In PA rings it also decreased the percentage increase in tension induced by hypoxia (TIH%) from the control value 48.82 +/- 5.75% to 10.02 +/- 3.62%, 2.14 +/- 0.96%, and 0.00% respectively, while in BA rings from 27.27 +/- 5.78% to 11.23 +/- 2.71%, 7.49 +/- 1.62%, and 1.45 +/- 1.13% respectively. The effects of 3, 4-DHAP on TIH% were partially blocked by indomethacin 10 M and L-NAME 10 M. The results showed that 3, 4-DHAP can decrease the hypoxic pulmonary and basilar vasoconstriction in vitro, which can be partially inhibited by cyclooxygenase inhibitor and NO/EDRF inhibitor.
在体外比较了3,4-二羟基苯丙酮（3,4-DHAP）对兔肺（PA）和基底动脉（BA）环缺氧性血管收缩反应的影响及其机制。不同浓度（2.64×10⁻⁴、7.92×10⁻⁴、2.376×10⁻³mol/L）的3,4-DHAP分别使PA环的基础张力降低32.39±9.4mg、68.96±26.54mg和145.60±58.07mg，而BA环的张力分别降低13.80±5.08mg、17.18±3.36mg和25.00±4.02mg。在PA环中，它还使缺氧诱导的张力增加百分比（TIH%）从对照值48.82±5.75%分别降至10.02±3.62%、2.14±0.96%和0.00%，而在BA环中从27.27±5.78%分别降至11.23±2.71%、7.49±1.62%和1.45±1.13%。10μM消炎痛和10μM左旋精氨酸甲酯（L-NAME）可部分阻断3,4-DHAP对TIH%的影响。结果表明，3,4-DHAP可在体外降低缺氧性肺血管和基底血管收缩，这可被环氧化酶抑制剂和NO/内皮舒张因子（EDRF）抑制剂部分抑制。
