Marchi A G, Bet N, Peisino M G, Vietti-Ramus M, Raspino M, Di Pietro P, Bernini G, Cantini L, Chiandetti L, Da Dalt L
IRCCS Istituto per l'Infanzia, Trieste, Italy.
J Toxicol Clin Toxicol. 1995;33(3):223-31. doi: 10.3109/15563659509017988.
Scores for severity grading of childhood poisoning may be useful in comparing different causes of poisoning, in order to identify the main risks and their changes over time. The Multicentre Study of Poisoning in Children score is based on four levels of severity (1-mild, 2-moderate, 3-severe, 4-very severe) involving nine target groups: seven relating to organ systems (gastrointestinal, nervous, respiratory, circulatory, renal, hepatic, skin), one to metabolic abnormalities and one to injuries from corrosive substances. Each patient is classified by the highest level attributed to any one of the nine groups. The score has been prospectively tested in 644 symptomatic children, aged 0-13 years, admitted to six pediatric hospitals of Northern Italy from January 1, 1991 to December 31, 1993. Poisoning was categorized as mild (1) in 357 children (53.8%), moderate (2) in 285 (42.9%), severe (3) in 18 (2.7%) and very severe (4) in 4 (0.6%). No deaths occurred. Severity grading according to The Multicentre Study of Poisoning in Children score confirms the prevalence of mild and moderate poisonings in children; the score seems to be an objective method suitable for epidemiological studies in different countries. Its clinical usefulness deserves more investigation.
儿童中毒严重程度分级评分对于比较不同中毒原因可能有用，以便确定主要风险及其随时间的变化。儿童中毒多中心研究评分基于四个严重程度级别（1 - 轻度、2 - 中度、3 - 重度、4 - 极重度），涉及九个目标组：七个与器官系统有关（胃肠道、神经、呼吸、循环、肾脏、肝脏、皮肤），一个与代谢异常有关，一个与腐蚀性物质所致损伤有关。每位患者根据九个组中任何一组所归属的最高级别进行分类。该评分已在1991年1月1日至1993年12月31日期间入住意大利北部六家儿科医院的644名0至13岁有症状儿童中进行了前瞻性测试。357名儿童（53.8%）的中毒被分类为轻度（1级），285名（42.9%）为中度（2级），18名（2.7%）为重度（3级），4名（0.6%）为极重度（4级）。无死亡病例发生。根据儿童中毒多中心研究评分进行的严重程度分级证实了儿童中轻度和中度中毒的普遍性；该评分似乎是一种适用于不同国家流行病学研究的客观方法。其临床实用性值得更多研究。
