Churi Shobha, Ramesh Madhan, Bhakta Krunal, Chris Jacob
Department of Pharmacy Practice, J.S.S. College of Pharmacy, J.S.S. University, S.S. Nagara, Mysore, Karnataka, India.
Chem Pharm Bull (Tokyo). 2012;60(7):859-64. doi: 10.1248/cpb.c12-00171.
The objective of this study was to assess the patterns, severity and clinical outcome of poisoning incidents. A prospective assessment was conducted over a period of 1 year in tertiary-care teaching hospitals. Glasgow coma scale (GCS), poisoning severity score (PSS), and snake bite severity score (SSS) were used to predict the severity of poisoning, and then compared to the clinical outcome. The study involved 212 patients with a mean age of 26.7±12.7 years. Pesticides were found to be the most common poisoning agents. The incidents of intentional poisoning (n=178) were higher than accidental (n=34) poisoning. Poisoning incidents were higher in male population (n=132) compared to female population (n=80). The poisoning incidents were predominantly higher among literates (n=155). The poisoning incidents were higher in rural areas (n=129), followed by urban (n=53) and semi-urban (n=30) areas. The poisoning incidents were highest in the middle class population (n=108), followed by poor class (n=101) and rich class (n=3) population. A majority of patients whose severity of illness was predicted to be mild to moderate recovered from the poisoning. In contrast, patients whose illness was predicted to be severe were either discharged with severe morbidity or deceased. There was a moderate correlation between GCS and PSS scoring systems (r=0.51, p<0.001).
本研究的目的是评估中毒事件的模式、严重程度及临床结局。在三级护理教学医院进行了为期1年的前瞻性评估。采用格拉斯哥昏迷量表(GCS)、中毒严重程度评分(PSS)和蛇咬伤严重程度评分(SSS)来预测中毒的严重程度,然后与临床结局进行比较。该研究纳入了212例患者,平均年龄为26.7±12.7岁。发现农药是最常见 的中毒剂。故意中毒事件(n = 178)高于意外中毒事件(n = 34)。男性人群(n = 132)的中毒事件高于女性人群(n = 80)。中毒事件在识字人群(n = 155)中占比更高。农村地区(n = 129)的中毒事件高于城市地区(n = 53)和半城市地区(n = 30)。中毒事件在中产阶级人群(n = 108)中最高,其次是贫困阶层(n = 101)和富裕阶层(n = 3)人群。大多数病情预计为轻度至中度的患者从中毒中康复。相比之下,病情预计为重度的患者要么出院时伴有严重的并发症,要么死亡。GCS和PSS评分系统之间存在中度相关性(r = 0.51,p<0.001)。