冠心病患者褪黑素夜间分泌受损。

Impaired nocturnal secretion of melatonin in coronary heart disease.

作者信息

Brugger P, Marktl W, Herold M

机构信息

Institute for Cardiovascular Diagnosis and Therapy, Salzburg, Austria.

出版信息

Lancet. 1995 Jun 3;345(8962):1408. doi: 10.1016/s0140-6736(95)92600-3.

DOI:10.1016/s0140-6736(95)92600-3

PMID:7760612

Abstract

Patients with coronary heart disease have increased nocturnal urinary noradrenaline. Because melatonin suppresses sympathetic activity, we measured serum melatonin concentrations at night (0200 h) in 15 patients with coronary heart disease. Melatonin was significantly lower in the patients than in 10 healthy controls (median 7.8 [interquartile range 6.5-11.8] vs 36.2 [32.2-42.5] pg/mL, p < 0.0001). Thus, impaired nocturnal secretion of melatonin is associated with coronary heart disease.

摘要

冠心病患者夜间尿去甲肾上腺素水平升高。由于褪黑素可抑制交感神经活动，我们对15例冠心病患者在夜间（凌晨2点）测量了血清褪黑素浓度。患者的褪黑素水平显著低于10名健康对照者（中位数7.8[四分位间距6.5 - 11.8] vs 36.2[32.2 - 42.5] pg/mL，p < 0.0001）。因此，夜间褪黑素分泌受损与冠心病有关。