Gardovskis J, Horstmann O, Ohmann C, Verreet P R, Yang Q, Wlasak R, Bösing N, Borchard F, Röher H D
Klinik für Allgemein- und Unfallchirurgie, Heinrich-Heine-Universität, Düsseldorf.
Langenbecks Arch Chir. 1995;380(2):75-81. doi: 10.1007/BF00186412.
The TNM system, including tumor infiltration (T category), lymph node infiltration (N category) and metastasis (M category), is a well-established system of prognostic factors. To evaluate the prognostic importance of patient characteristics and tumor parameters 5 clinical and 13 pathological factors were analyzed. Data on 200 consecutive patients with histologically verified stomach cancer were prospectively recorded using a standardized form. In the subgroup with curative resection (R0, n = 108) a uni- and multivariate analysis was performed with respect to 5-year survival. In the univariate analysis statistical significance was demonstrated for the following factors: tumor size, tumor localization, T category, N category, number of infiltrated lymph nodes infiltrated, lymph node compartments, tumor stage, lymph node ratio: infiltrated/inspected. Multivariate analysis, taking into consideration the interaction between prognostic factors, revealed only two factors as statistically significant: number of infiltrated lymph nodes and tumor size. Our results and those in the literature indicate that the infiltration of lymph nodes is the most relevant prognostic factor. In addition to the TNM system the number of infiltrated lymph nodes seems to be of prognostic importance.
TNM系统包括肿瘤浸润（T分类）、淋巴结浸润（N分类）和转移（M分类），是一个成熟的预后因素系统。为了评估患者特征和肿瘤参数的预后重要性，分析了5个临床因素和13个病理因素。使用标准化表格前瞻性记录了200例经组织学证实的胃癌连续患者的数据。在根治性切除的亚组（R0，n = 108）中，对5年生存率进行了单因素和多因素分析。在单因素分析中，以下因素具有统计学意义：肿瘤大小、肿瘤位置、T分类、N分类、浸润淋巴结数量、淋巴结分区、肿瘤分期、淋巴结比率：浸润/检查。多因素分析考虑了预后因素之间的相互作用，仅显示两个因素具有统计学意义：浸润淋巴结数量和肿瘤大小。我们的结果以及文献中的结果表明，淋巴结浸润是最相关的预后因素。除TNM系统外，浸润淋巴结数量似乎也具有预后重要性。
