Korenaga D, Haraguchi M, Okamura T, Baba H, Saito A, Sugimachi K
Department of Surgery II, Kyushu University Faculty of Medicine, Fukuoka, Japan.
Arch Surg. 1989 Mar;124(3):314-8. doi: 10.1001/archsurg.1989.01410030064011.
The relationship between DNA ploidy and tumor invasion in 254 patients with gastric carcinoma was studied, with particular emphasis on histopathologic features. In the differentiated type of adenocarcinoma, there were aneuploid lesions characterized by a relatively high incidence of lymph node metastasis and hematogenous recurrence, even when the invasion was limited to the submucosa. In the undifferentiated type, aneuploid lesions were rarely seen at the early stage, but the frequency remarkably increased with invasion into the deeper layers. Nodal involvement and disseminating metastasis were evident with serosal invasion. Analyzed by a multivariate Cox model, DNA ploidy significantly correlated with prognosis. Thus, DNA ploidy is a major determinant of survival, and the behavior of an aneuploid carcinoma is apparently controlled by individual histologic type.
研究了254例胃癌患者的DNA倍体与肿瘤侵袭之间的关系，特别强调了组织病理学特征。在分化型腺癌中，存在非整倍体病变，其特征是淋巴结转移和血行复发的发生率相对较高，即使侵袭仅限于黏膜下层。在未分化型中，早期很少见到非整倍体病变，但随着侵袭至更深层，其频率显著增加。浆膜侵犯时可见淋巴结受累和播散性转移。通过多变量Cox模型分析，DNA倍体与预后显著相关。因此，DNA倍体是生存的主要决定因素，非整倍体癌的行为显然受个体组织学类型的控制。
