Melcer T, Gonzalez D, Somes C, Riley E P
Department of Psychology, San Diego State University, CA 92120, USA.
Neurotoxicol Teratol. 1995 Mar-Apr;17(2):103-10. doi: 10.1016/0892-0362(94)00058-l.
It has been suggested that differential sensitivity to alcohol might influence the severity of effects seen in offspring following gestational alcohol exposure and data exist to support this contention. Previously, we found that neonatal alcohol treatment produced greater increases in activity at the time of weaning in alcohol preferring (P) than by alcohol nonpreferring (NP) rat lines. Whereas these lines were genetically selected for extremes in alcohol preference they also differ on "sensitivity" to alcohol. Neonatal exposure in rats is used to model human third trimester alcohol exposure and the present study examined motor skills in P and NP rats following such exposure. On postnatal days 4 through 7, P and NP rats received a daily dose of 6 g/kg in four administrations 2 h apart. The alcohol was delivered in a milk solution through an indwelling intragastric cannula. Artificially reared and normally reared controls were included in the study. At 21 and 43 days of age, rats were tested for abnormalities in gait by walking an inclined runway and for dysfunction in balance using the parallel bar test. Neonatal alcohol exposure increased falling from the bars and altered gait and these effects were similar in the P and NP lines. The parallel bar test was generally too difficult for the NP rats, limiting the utility of this test in trying to determine the effects of differential alcohol sensitivity. Thus, the present results suggest that neonatal alcohol exposure had equivalent effects on gait and balance, as measured by falling from parallel bars, in P and NP rats.(ABSTRACT TRUNCATED AT 250 WORDS)
有人提出，对酒精的不同敏感性可能会影响孕期酒精暴露后代所出现效应的严重程度，并且有数据支持这一论点。此前，我们发现，断奶时，酒精偏好型（P）大鼠品系经新生儿期酒精处理后活动增加幅度大于酒精非偏好型（NP）大鼠品系。虽然这些品系是根据酒精偏好的极端情况进行基因选择的，但它们对酒精的“敏感性”也存在差异。大鼠新生儿期暴露用于模拟人类妊娠晚期酒精暴露，本研究考察了此类暴露后P和NP大鼠的运动技能。在出生后第4至7天，P和NP大鼠每隔2小时分四次接受每日剂量为6 g/kg的酒精。酒精通过留置胃内插管以乳剂形式给药。研究纳入了人工饲养和正常饲养的对照组。在21日龄和43日龄时，通过让大鼠在倾斜跑道上行走测试其步态异常，并使用双杠试验测试其平衡功能障碍。新生儿期酒精暴露增加了大鼠从双杠上掉落的次数，并改变了步态，这些效应在P和NP品系中相似。双杠试验对NP大鼠通常太难，限制了该试验在确定酒精敏感性差异影响方面的效用。因此，目前的结果表明，通过双杠掉落次数衡量，新生儿期酒精暴露对P和NP大鼠的步态和平衡有同等影响。（摘要截断于250字）
