“bric à brac”的BTB结构域在体外介导二聚化。
The BTB domain of bric à brac mediates dimerization in vitro.
作者信息
Chen W, Zollman S, Couderc J L, Laski F A
机构信息
Department of Biology, University of California, Los Angeles 90024, USA.
出版信息
Mol Cell Biol. 1995 Jun;15(6):3424-9. doi: 10.1128/MCB.15.6.3424.
Abstract
The gene bric à brac (bab) is required for the proper development of the limbs and ovary in Drosophila melanogaster. bab encodes a BTB domain (also called a POZ domain), an approximately 115-amino-acid conserved motif found primarily in the N termini of zinc finger proteins. In this paper, we show that the BTB domain of bab can mediate protein dimerization in vitro. In addition, we demonstrate that the first 51 amino acids of the bab BTB domain are sufficient for dimerization, and we identify amino acids within this region that are required for binding.
摘要
基因bric à brac（bab）对于黑腹果蝇的肢体和卵巢的正常发育是必需的。bab编码一个BTB结构域（也称为POZ结构域），这是一个约115个氨基酸的保守基序，主要存在于锌指蛋白的N端。在本文中，我们表明bab的BTB结构域可以在体外介导蛋白质二聚化。此外，我们证明bab BTB结构域的前51个氨基酸足以实现二聚化，并且我们确定了该区域内结合所需的氨基酸。
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