Menachem Y, Odes H S, Neumann L, Niv Y
Department of Gastroenterology, Soroka Medical Center of Kupat Holim Klalit, Beer Sheva, Israel.
Public Health Rev. 1995;23(1):47-58.
A knowledge of the clinical and epidemiological features of duodenal and gastric ulcer is of importance to clinicians and other health care providers. These aspects of ulcer disease have not been studied previously in the Negev region of southern Israel, which is home to 300,000 Jews and 60,000 Bedouin Arabs.
Clinical, demographic and risk factors were analyzed in a case series of benign duodenal and gastric ulcers (first or recurrent attack) diagnosed at endoscopy at the Soroka Medical Center in the years 1989-1990.
There were 336 cases of duodenal ulcer (321 cases in Jews, 15 in Bedouins) and 79 cases of gastric ulcer (all in Jews). The annual rate of endoscopically-detected duodenal ulcer was 54/10(5) in Jews and 13/10(5) in Bedouins. The annual ratio of endoscopically-detected gastric ulcer in Jews was 13/10(5). The ratio of male to female patients was 2.7 for duodenal ulcer in Jews and Bedouins, and 1.9 for gastric ulcer in Jews. The mean age +/- standard deviation at diagnosis was 48 +/- 17 years for duodenal ulcer and 63 +/- 15 years for gastric ulcer (p < 0.001). Duodenal ulcer was significantly commoner than gastric ulcer at all ages, but the ratio DU:GU decreased with increasing age, so that by age 48 years, 20% of all endoscopically-diagnosed ulcers were GU. Of several risk factors examined, smoking was associated with duodenal ulcer (p < 0.05) but not gastric ulcer. Occupation was not a risk factor. Duodenal ulcer was 1.3 times more frequent in winter than summer.
Endoscopically-diagnosed duodenal and gastric ulcer is commoner in Jews than Bedouins and in men than women. Duodenal ulcer is commoner than gastric ulcer and presents at a younger age. Smoking is a risk factor for duodenal ulcer, and European and American ethnic origin is a risk factor for duodenal and gastric ulcers. Bleeding is associated with one-third of endoscopically-diagnosed ulcers in this institution.
了解十二指肠溃疡和胃溃疡的临床及流行病学特征对临床医生和其他医疗保健人员很重要。以色列南部内盖夫地区此前尚未对溃疡病的这些方面进行过研究，该地区有30万犹太人和6万贝都因阿拉伯人。
对1989 - 1990年在索罗卡医疗中心经内镜诊断的一系列良性十二指肠溃疡和胃溃疡（初发或复发）病例的临床、人口统计学和危险因素进行分析。
有336例十二指肠溃疡（321例犹太人，15例贝都因人）和79例胃溃疡（均为犹太人）。犹太人中经内镜检测到的十二指肠溃疡年发病率为54/10⁵，贝都因人为13/10⁵。犹太人中经内镜检测到的胃溃疡年发病率为13/10⁵。十二指肠溃疡患者男女比例在犹太人和贝都因人中为2.7，胃溃疡在犹太人中为1.9。诊断时的平均年龄±标准差，十二指肠溃疡为48±17岁，胃溃疡为63±15岁（p<0.001）。十二指肠溃疡在各年龄段均明显比胃溃疡更常见，但十二指肠溃疡与胃溃疡的比例随年龄增长而下降，到48岁时，所有经内镜诊断的溃疡中有20%为胃溃疡。在检查的几个危险因素中，吸烟与十二指肠溃疡相关（p<0.05），但与胃溃疡无关。职业不是危险因素。十二指肠溃疡在冬季比夏季多1.3倍。
经内镜诊断的十二指肠溃疡和胃溃疡在犹太人中比在贝都因人中更常见，在男性中比在女性中更常见。十二指肠溃疡比胃溃疡更常见，且发病年龄更小。吸烟是十二指肠溃疡的危险因素，欧美族裔是十二指肠溃疡和胃溃疡的危险因素。在该机构，出血与三分之一经内镜诊断的溃疡有关。
