Katz J D, Benoist C, Mathis D
Institut de Génétique et de Biologie Moléculaire et Cellulaire, INSERM-CNRS-Université Louis Pasteur, Illkirch, CU de Strasbourg, France.
Science. 1995 May 26;268(5214):1185-8. doi: 10.1126/science.7761837.
It has been proposed that the development of insulin-dependent diabetes is controlled by the T helper 1 (TH1) versus TH2 phenotype of autoreactive TH cells: TH1 cells would promote diabetes, whereas TH2 cells would actually protect from disease. This proposition was tested by establishing cultures of TH1 and TH2 cells that express an identical diabetogenic T cell receptor and comparing their ability to initiate disease in neonatal nonobese diabetic mice. TH1-like cells actively promoted diabetes; TH2-like cells invaded the islets but did not provoke disease--neither did they provide substantial protection.
有人提出，胰岛素依赖型糖尿病的发展受自身反应性辅助性T细胞1（TH1）与辅助性T细胞2（TH2）表型的控制：TH1细胞会促进糖尿病，而TH2细胞实际上会预防疾病。通过建立表达相同致糖尿病T细胞受体的TH1和TH2细胞培养物，并比较它们在新生非肥胖糖尿病小鼠中引发疾病的能力，对这一观点进行了验证。TH1样细胞积极促进糖尿病；TH2样细胞侵入胰岛，但不会引发疾病，也不会提供实质性的保护。
