Allen D M, Ling M L
Department of Infectious Diseases, Communicable Disease Centre, Singapore.
Singapore Med J. 1994 Dec;35(6):626-30.
There has been a proliferation of antimicrobial agents in the market and we can expect many more new agents to be available for use in the hospital and community later. In the outpatient setting, the number of oral antimicrobial agents are varied, providing greater flexibility in managing community acquired infections. Unfortunately, the extensive use of antimicrobial agents has contributed to the development of resistance of some bacteria to multiple antimicrobials. This paper will review the basis of activity of antimicrobial agents commonly used in the outpatient clinic. The spectrum of antibacterial activity of these agents is discussed in relation to the common organisms encountered in general practice. Guidelines for the control of the development of bacterial antimicrobial resistance are also given.
市场上的抗菌药物种类不断增加，我们预计以后会有更多新型药物可供医院和社区使用。在门诊环境中，口服抗菌药物种类多样，为治疗社区获得性感染提供了更大的灵活性。不幸的是，抗菌药物的广泛使用导致了一些细菌对多种抗菌药物产生耐药性。本文将综述门诊常用抗菌药物的作用基础。将结合全科医疗中常见的病原体讨论这些药物的抗菌谱。还给出了控制细菌对抗菌药物耐药性发展的指南。
