Dixon R A, Atkinson R E, Kenyon C, Lamb D, Thornton J A, Woodhead S
Br J Anaesth. 1976 May;48(5):431-9. doi: 10.1093/bja/48.5.431.
A randomized partial cross-over clinical trial of two intravenous techniques for outpatient conservative dentistry was performed in 61 patients. Subanaesthetic incremental doses of Althesin were used at 52 sessions and a single sedative dose of diazepam at 45 sessions. Each technique produced similar cardiovascular and respiratory changes. With Althesin, recovery after operation was more rapid and there was some evidence of a stronger anxiolytic effect and of less frequent and less severe thrombophlebitis. In contrast, Althesin was sometimes associated with jaw tremor or shivering and was less frequently mentioned by those patients who expressed a strong preference for one of the two techniques.
对61例患者进行了一项关于门诊保守牙科两种静脉注射技术的随机部分交叉临床试验。在52次治疗中使用亚麻醉递增剂量的阿法沙龙，在45次治疗中使用单次镇静剂量的地西泮。每种技术产生相似的心血管和呼吸变化。使用阿法沙龙时，术后恢复更快，有证据表明其抗焦虑作用更强，血栓性静脉炎的发生率更低、症状更轻。相比之下，阿法沙龙有时会伴有下颌震颤或寒战，在那些强烈偏好这两种技术之一的患者中，提及阿法沙龙的频率较低。
