Kauste A
Ann Chir Gynaecol. 1976;65(4):239-48.
The cumulative effects and post-anaesthetic recovery of Althesin were studied by comparing the drug with methohexitone in a series of 60 patients undergoing surgery for varicose veins. Anaesthesia was maintained with each anaesthetic agent in 30 patients by administration of intermittent doses of the respective drugs in accordance with the surgical stimulus. When repeat doses were required at intervals of 2 to 5 minutes, the fall off in requirements was observed with both anaesthetics, more distinctly with Althesin than with methohexitone. No significant difference could be observed in the time required for immediate awakening after the two drugs. However, the majority of the patients anaesthetized with Althesin displayed a peculiar lack of mental clarity for a short period after recovering consciousness. The recovery from anaesthesia was studied by various tests and observations. Recovery after Althesin appeared to proceed slightly faster than after methohexitone. When Althesin was required in high total dosage (exceeding 150 mu1/kg), the immediate awakening was associated with emotional upset and confusion. Frequency of nausea and vomiting after anaesthesia was considerably higher in the Althesin group than in the methohexitone group. These symptoms might be toxic due to the excessive dosage given. Using the induction time as a basis for calculation of the potency ratio, Althesin and methohexiton were found to have the ratio of 1:33 (expressed in mu1/kg : mg/kg).
通过在60例接受静脉曲张手术的患者中，将阿耳忒辛（Althesin）与美索比妥（methohexitone）进行比较，研究了阿耳忒辛的累积效应和麻醉后恢复情况。30例患者分别使用这两种麻醉剂，根据手术刺激间歇性给药维持麻醉。当每隔2至5分钟需要重复给药时，两种麻醉剂的需求量均出现下降，阿耳忒辛比美索比妥更明显。两种药物麻醉后立即苏醒所需时间无显著差异。然而，大多数接受阿耳忒辛麻醉的患者在意识恢复后的短时间内表现出一种特殊的精神清晰度不足。通过各种测试和观察研究了麻醉后的恢复情况。阿耳忒辛麻醉后的恢复似乎比美索比妥稍快。当阿耳忒辛的总剂量较高（超过150μl/kg）时，立即苏醒会伴有情绪不安和混乱。阿耳忒辛组麻醉后恶心和呕吐的发生率明显高于美索比妥组。这些症状可能是由于给药过量所致。以诱导时间为基础计算效价比，发现阿耳忒辛与美索比妥的效价比为1:33（以μl/kg : mg/kg表示）。
