在高冠状动脉风险和低冠状动脉风险的男性中，颈动脉壁内膜中层厚度与胰岛素介导的葡萄糖代谢有关。
Carotid artery wall intima-media thickness is associated with insulin-mediated glucose disposal in men at high and low coronary risk.
作者信息
Agewall S, Fagerberg B, Attvall S, Wendelhag I, Urbanavicius V, Wikstrand J
机构信息
Department of Medicine, Sahlgrenska University Hospital, Göteborg University, Sweden.
出版信息
Stroke. 1995 Jun;26(6):956-60. doi: 10.1161/01.str.26.6.956.
BACKGROUND AND PURPOSE
The aim of this investigation was to examine the relationship between insulin sensitivity and intima-media thickness in the common carotid artery.
METHODS
Ultrasound examinations of the common carotid artery and hyperinsulinemic euglycemic clamp examinations were performed in a group (n = 25) of men aged 57 to 77 years at high risk for atherosclerotic disease (hypertension and at least one of the following factors: hypercholesterolemia and/or smoking) and in an age-matched low-risk group (n = 23) with no cardiovascular risk factors. Subjects with cardiovascular disease or diabetes mellitus were excluded.
RESULTS
A significant negative relationship between insulin sensitivity index and common carotid maximum intima-media thickness was observed in both the high-risk group (r = -.45, P < .05) and in the low-risk group (r = -.59, P < .01).
CONCLUSIONS
Our results suggest that an increase in intimamedia thickness, as a possible expression of early atherosclerosis, is negatively related to insulin sensitivity.
背景与目的
本研究旨在探讨胰岛素敏感性与颈总动脉内膜中层厚度之间的关系。
方法
对一组（n = 25）年龄在57至77岁、患动脉粥样硬化疾病风险较高（患有高血压且具备以下至少一项因素：高胆固醇血症和/或吸烟）的男性以及一组年龄匹配、无心血管危险因素的低风险组（n = 23）男性进行颈总动脉超声检查和高胰岛素正常血糖钳夹试验。排除患有心血管疾病或糖尿病的受试者。
结果
在高风险组（r = -.45，P < .05）和低风险组（r = -.59，P < .01）中，均观察到胰岛素敏感性指数与颈总动脉最大内膜中层厚度之间存在显著的负相关关系。
结论
我们的研究结果表明，内膜中层厚度增加作为早期动脉粥样硬化的一种可能表现，与胰岛素敏感性呈负相关。
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