Cao Chao, Chen Zhong-Bo, Sun Shi-Fang, Yu Yi-Ming, Ding Qun-Li, Deng Zai-Chun
1] Department of Respiratory Medicine, the Affiliated Hospital of School of Medicine, Ningbo University, Ningbo 315020, China [2] Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China [3].
Sci Rep. 2013 Dec 11;3:3473. doi: 10.1038/srep03473.
A total of 87 patients were enrolled and bronchoalveolar lavage fluid (BALF) samples were obtained from all subjects. A significant difference was found in BALF VEGF-C level between patients with squamous cell carcinoma and benign diseases (P = 0.043). In addition, the concentration of NSE in BALF form the malignant group was significantly higher compared with that of the benign groups (P = 0.018). However, no statistical difference was observed in BALF CEA (P = 0.375) or CYFRA21-1 (P = 0.838) between lung cancer patients and nonmalignant controls. With a cut-off value of 2.06 ng/ml, NSE had a sensitivity of 72.9%, a specificity of 69.2%, respectively, in predicting the malignant nature of pulmonary mass. Our study observed that the level of VEGF-C was increased in BALF of patients with squamous cell carcinoma. Moreover, we found that NSE was significantly higher in BALF of lung cancer patients than in benign diseases.
共纳入87例患者，并采集了所有受试者的支气管肺泡灌洗（BALF）样本。鳞状细胞癌患者与良性疾病患者的BALF中VEGF-C水平存在显著差异（P = 0.043）。此外，恶性组BALF中NSE的浓度显著高于良性组（P = 0.018）。然而，肺癌患者与非恶性对照组之间的BALF中CEA（P = 0.375）或CYFRA21-1（P = 0.838）未观察到统计学差异。以2.06 ng/ml为临界值，NSE在预测肺肿块的恶性性质时，敏感性分别为72.9%，特异性为69.2%。我们的研究观察到，鳞状细胞癌患者的BALF中VEGF-C水平升高。此外，我们发现肺癌患者BALF中的NSE显著高于良性疾病患者。
