Kanoh N
Department of Otolaryngology, Hyogo College of Medicine, Japan.
Acta Otolaryngol. 1995 Jan;115(1):27-30. doi: 10.3109/00016489509133341.
It is believed that the function of the stria vascularis in the cochlea is to produce endolymph. However, the mechanisms that maintain and control the function of the stria vascularis remain unclear. In the present study, to clarify the role of humoral substances in the stria vascularis, a cerium-based method was used to investigate the ultracytochemical effects of intraperitoneal dopamine administration on ouabain-sensitive, K(+)-dependent, p-nitrophenylphosphatase (K-NPPase) activity, which is the second step in the formation of the Na-K ATPase complex, in the stria vascularis of guinea pigs. Na-K ATPase activity was shown to be completely inhibited after dopamine administration. This observation suggests that dopamine inhibits Na-K ATPase activity in the marginal cells of the stria vascularis, and that the stria vascularis may have dopamine receptors. Catecholamines may play an important role in the maintenance and/or control of stria vascularis function.
人们认为，耳蜗内血管纹的功能是产生内淋巴。然而，维持和控制血管纹功能的机制仍不清楚。在本研究中，为了阐明体液物质在血管纹中的作用，采用基于铈的方法，研究腹腔注射多巴胺对豚鼠血管纹中哇巴因敏感、钾依赖的对硝基苯磷酸酶（K-NPPase）活性的超微细胞化学效应，K-NPPase活性是钠钾ATP酶复合体形成的第二步。结果显示，注射多巴胺后钠钾ATP酶活性被完全抑制。这一观察结果表明，多巴胺抑制血管纹边缘细胞中的钠钾ATP酶活性，并且血管纹可能具有多巴胺受体。儿茶酚胺可能在血管纹功能的维持和/或控制中发挥重要作用。
