Kanoh N, Nomura J
Department of Otolaryngology, Hyogo College of Medicine, Japan.
Acta Otolaryngol Suppl. 1995;520 Pt 2:381-3. doi: 10.3109/00016489509125276.
It is believed that the function of the stria vascularis in the cochlea is to produce endolymph. The mechanisms that maintain or control the function of the stria vascularis, however, remain unclear. In a previous study, we investigated the ultracytochemical effects of one-shot reserpine administration on the Na-K ATPase activity of the stria vascularis in guinea pigs. Na-K ATPase activity was shown to be completely inhibited 3-20 days after reserpinization, whereas in the present study at 20 days after reserpinization and following L-threo DOPS treatment, Na-K ATPase activity was detectable. As reserpine is an adrenergic neuron blocker, and L-threo DOPS is the precursor of noradrenaline, it seems that noradrenaline converted from L-threo DOPS was able to restore the Na-K ATPase activity in the reserpinized animals. These results suggest that catecholamines may play an essential role in the maintenance or control of the Na-K ATPase activity, and that the stria vascularis may be one of the target organs of catecholamines.
人们认为，耳蜗内血管纹的功能是产生内淋巴。然而，维持或控制血管纹功能的机制仍不清楚。在先前的一项研究中，我们研究了一次性给予利血平对豚鼠血管纹钠钾ATP酶活性的超微细胞化学效应。结果显示，利血平化后3 - 20天，钠钾ATP酶活性被完全抑制，而在本研究中，利血平化20天后并经L - 苏式 - 二羟基苯丝氨酸（L - threo DOPS）处理后，钠钾ATP酶活性可检测到。由于利血平是一种肾上腺素能神经元阻滞剂，而L - 苏式 - 二羟基苯丝氨酸是去甲肾上腺素的前体，似乎从L - 苏式 - 二羟基苯丝氨酸转化而来的去甲肾上腺素能够恢复利血平化动物体内的钠钾ATP酶活性。这些结果表明，儿茶酚胺可能在维持或控制钠钾ATP酶活性中起重要作用，并且血管纹可能是儿茶酚胺的靶器官之一。
