Kanoh N
Department of Otolaryngology, Hyogo College of Medicine, Japan.
Laryngoscope. 1994 Feb;104(2):197-200. doi: 10.1288/00005537-199402000-00013.
The function of the stria vascularis in the cochlea is believed to be the production of endolymph. The mechanisms that maintain or control the function of the stria vascularis, however, remain unclear. In the present study, the effects of one-shot reserpine administration on the NaK ATPase activity of the stria vascularis in guinea pigs were investigated. NaK ATPase activity was shown to be completely inhibited 3 to 20 days after reserpinization, and was detectable again 60 days after reserpinization. As reserpine is an adrenergic neuron blocker, these results suggest that catecholamines may play an essential role in the maintenance or control of NaK ATPase activity, and that the stria vascularis may be one of the target organs of catecholamines.
血管纹在耳蜗中的功能被认为是产生内淋巴。然而，维持或控制血管纹功能的机制仍不清楚。在本研究中，研究了一次性给予利血平对豚鼠血管纹钠钾ATP酶活性的影响。结果显示，利血平化后3至20天，钠钾ATP酶活性被完全抑制，利血平化60天后再次检测到该活性。由于利血平是一种肾上腺素能神经元阻滞剂，这些结果表明儿茶酚胺可能在维持或控制钠钾ATP酶活性中起重要作用，并且血管纹可能是儿茶酚胺的靶器官之一。
