Thin-layer chromatographic analysis of some benzofuran derivatives in human plasma.

Benzofuran derivatives: amiodarone, benziodarone, benzbromarone and benzarone, extracted from plasma, were separated by TLC method on silica gel by ascending and horizontal developments, using suitable mobile phases. The substances were identified by reaction with potassium permanganate solution, either by Dragendorff (modified after Amelink) or Sonnenschein reagents (up to the amounts of 250 ng of amiodarone and benzarone and 500 ng of benziodarone and benzbromarone).