Misztal G
Katedra i Zakład Chemii Leków Akademii Medycznej, Lublinie.
Acta Pol Pharm. 1990;47(5-6):5-8.
Pentazocine, piritramide and methadone, when extracted from blood or plasma with ether at pH ca. 12, were separated by TLC method on alumina or silica gel by ascending technique on 5 x 20 cm and 2.5 x 7.5 cm plates and also by horizontal development, using suitable mobile phases. The substances were identified by reaction with potassium iodoplatinate or 20% Na2CO3 solution (up to the amount 2 micrograms pentazocine, 0.5 microgram piritramide and 1.5 micrograms methadone.
喷他佐辛、匹利卡明和美沙酮在pH约为12的条件下用乙醚从血液或血浆中提取后,通过TLC法在氧化铝或硅胶板上进行分离,在5×20 cm和2.5×7.5 cm的板上采用上行技术,也可采用水平展开,使用合适的流动相。通过与碘化铂钾或20%碳酸钠溶液反应来鉴定这些物质(喷他佐辛含量高达2微克、匹利卡明含量高达0.5微克、美沙酮含量高达1.5微克)。