[初次免疫应答过程中淋巴细胞受体对半抗原亲和力的动力学研究]
[Study of the dynamics of lymphocyte receptor affinity for hapten in the process of the primary immune response].
作者信息
Khazanova I V
出版信息
Biull Eksp Biol Med. 1975 Oct;80(10):83-6.
PMID:776250
Abstract
The affinity of the lymphocyte receptors for DNP-determinants was studied by free hapten inhibition of rosette-forming cells. The avidity of the antigen-binding lymphoid cells was found to increase with the advance of time after the immunization. The results suggest that an increase in the cellular avidity during the immune response depended on both the affinity of the gamma-globulin receptors and their concentration on the cell surface.
摘要
通过游离半抗原对玫瑰花结形成细胞的抑制作用，研究了淋巴细胞受体对二硝基苯基（DNP）决定簇的亲和力。发现抗原结合淋巴细胞的亲合力在免疫后随时间推移而增加。结果表明，免疫反应过程中细胞亲合力的增加取决于γ-球蛋白受体的亲和力及其在细胞表面的浓度。
相似文献
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[Study of the dynamics of lymphocyte receptor affinity for hapten in the process of the primary immune response].[初次免疫应答过程中淋巴细胞受体对半抗原亲和力的动力学研究]
Biull Eksp Biol Med. 1975 Oct;80(10):83-6.
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Studies on the control of antibody synthesis. VII. Change in affinity of direct and indirect plaque-forming cells with time after immunization in the mouse: loss of high affinity plaques late after immunization.抗体合成控制的研究。VII. 小鼠免疫后直接和间接噬斑形成细胞亲和力随时间的变化：免疫后期高亲和力噬斑的丧失
Immunology. 1975 Oct;29(4):629-41.
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Vitamin A: adjuvant and steroid antagonist in the immune response.维生素A：免疫反应中的佐剂和类固醇拮抗剂。
J Immunol. 1973 Nov;111(5):1376-80.
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The immunological properties of haptens coupled to thymus-independent carrier molecules. II. The influence of the graft-versus-host reaction on primary antibody responses to hapten-coupled polysaccharides and proteins.与非胸腺依赖性载体分子偶联的半抗原的免疫学特性。II. 移植物抗宿主反应对针对半抗原偶联多糖和蛋白质的初次抗体反应的影响。
Eur J Immunol. 1974 Jul;4(7):505-11. doi: 10.1002/eji.1830040712.
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Role of epitope density in the induction of tolerance and immunity with thymus-independent antigens. III. Interaction of epitope density and receptor avidity.表位密度在非胸腺依赖性抗原诱导耐受和免疫中的作用。III. 表位密度与受体亲和力的相互作用。
Eur J Immunol. 1976 Sep;6(9):646-50. doi: 10.1002/eji.1830060910.
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Hapten-specific tolerance in mice. I. Induction with hapten-coupled syngeneic erythrocytes.小鼠对半抗原的特异性耐受。I. 用半抗原偶联的同基因红细胞诱导
Eur J Immunol. 1974 Apr;4(4):261-8. doi: 10.1002/eji.1830040407.
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Priming or tolerization of the B- and Th2-dependent immune response by the oral administration of OVA-DNP is determined by the antigen dosage.通过口服卵清蛋白-二硝基苯（OVA-DNP）引发或诱导B细胞和Th2细胞依赖性免疫反应取决于抗原剂量。
Cell Immunol. 1998 Nov 25;190(1):1-11. doi: 10.1006/cimm.1998.1356.
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