抗体合成控制的研究。VII. 小鼠免疫后直接和间接噬斑形成细胞亲和力随时间的变化：免疫后期高亲和力噬斑的丧失
Studies on the control of antibody synthesis. VII. Change in affinity of direct and indirect plaque-forming cells with time after immunization in the mouse: loss of high affinity plaques late after immunization.
作者信息
Goidl E A, Barondess J J, Siskind G W
出版信息
Immunology. 1975 Oct;29(4):629-41.
Abstract
The change in avidity of anti-hapten antibody with time after immunization was studied in mice at the level of the antibody-forming cell. A progressive increase in avidity was seen in both direct and indirect plaque-forming cells. Late (38 days) after immunization with a large dose of antigen there was a preferential loss of high avidity plaque-forming cells and the average avidity decreased. High avidity memory cells were still present since boosting resulted in the prompt appearance of very high avidity plaque-forming cells. There was a strong positive correlation between the avidity of the direct and the indirect plaque-forming cells present in the same spleen. A pattern of change in avidity and heterogeneity of avidity similar to that observed with intact animals was seen in lethally irradiated mice reconstituted with normal spleen and thymus cells.
摘要
在抗体形成细胞水平上研究了小鼠免疫后抗半抗原抗体亲和力随时间的变化。直接和间接空斑形成细胞的亲和力均呈逐渐增加。用大剂量抗原免疫后晚期（38天），高亲和力空斑形成细胞优先丢失，平均亲和力下降。由于再次免疫导致出现非常高亲和力的空斑形成细胞，高亲和力记忆细胞仍然存在。同一脾脏中存在的直接和间接空斑形成细胞的亲和力之间存在很强的正相关。在用正常脾细胞和胸腺细胞重建的致死性照射小鼠中，观察到与完整动物相似的亲和力变化模式和亲和力异质性。
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