Aĭrapet'ian G P, Maĭskiĭ I N, Gudkova R B, Aĭrapet'ian L K
Biull Eksp Biol Med. 1976 May;81(5):591-4.
The activity of acid phosphatase and some dehydrogenases in the peripheral blood lymphocytes was compared with the development of cell immunity, assessed by the macrophage migration inhibition test, during chemical carcinogenesis in Wistar rats. At the early stages of the carcinogenesis the changes of the enzymatic activities of succinic dehydrogenase and acid phosphatase proved to coordinate with a sufficiently high level of the immunological reactivity of the cell type in 66% of the animals. With the progressive growth of the tumours there occurred a disturbance of the enzymatic balance in the lymphoid cells and a simultaneous decrease in the immunological response.
在Wistar大鼠化学致癌过程中，通过巨噬细胞移动抑制试验评估细胞免疫的发展情况，并将外周血淋巴细胞中酸性磷酸酶和某些脱氢酶的活性与之进行比较。在致癌作用的早期阶段，66%的动物中琥珀酸脱氢酶和酸性磷酸酶的酶活性变化与细胞类型的免疫反应性处于足够高的水平相协调。随着肿瘤的逐渐生长，淋巴细胞中的酶平衡出现紊乱，同时免疫反应降低。
