Murakawa M, Okamura T, Harada M, Esaki T, Kamura T, Shibuya T, Niho Y
First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Ann Clin Lab Sci. 1995 Jan-Feb;25(1):31-8.
In two cases of transfusion-associated graft-versus-host disease (TA-GVHD), severe bleeding tendencies were observed besides the characteristic features of the disease. An elevation of fibrin degradation products (FDP), D-dimer, thrombin-antithrombin III complex (TAT) and plasmin-alpha 2 plasmin inhibitor complex (PIC), was revealed. These findings were compatible with disseminated intravascular coagulation (DIC). To our knowledge, the association of TA-GVHD and DIC has not been described, and it is our speculation that allogeneic immune reactions may play some pathogenic role in developing DIC in TA-GVHD. The DIC may be responsible for the rapid progression of multiple organ failure (MOF) in TA-GVHD.
在两例输血相关移植物抗宿主病（TA-GVHD）中，除了该病的特征性表现外，还观察到严重的出血倾向。检测发现纤维蛋白降解产物（FDP）、D-二聚体、凝血酶-抗凝血酶III复合物（TAT）和纤溶酶-α2纤溶酶抑制物复合物（PIC）升高。这些发现符合弥散性血管内凝血（DIC）。据我们所知，尚未见TA-GVHD与DIC相关性的描述，我们推测同种异体免疫反应可能在TA-GVHD发生DIC过程中发挥某种致病作用。DIC可能是TA-GVHD中多器官功能衰竭（MOF）快速进展的原因。
