Kondo S, Shinomura Y, Kanayama S, Higashimoto Y, Kiyohara T, Yasunaga Y, Kitamura S, Ueyama H, Imamura I, Fukui H
Second Department of Internal Medicine, Osaka University Medical School, Suita, Japan.
Biochem Biophys Res Commun. 1995 May 25;210(3):960-5. doi: 10.1006/bbrc.1995.1750.
Helicobacter pylori (H. pylori) induces hyperproliferation of the gastric mucosa. This study was designed to clarify whether H. pylori infection is involved in the gene expression of hepatocyte growth factor (HGF), a potent stimulator of cell proliferation in gastric mucosa. Levels of HGF mRNA were determined by a reverse transcription-polymerase chain reaction in endoscopic gastric biopsy specimens from 9 control subjects and 9 patients with H. pylori infection. In patients with H. pylori infection, levels of HGF mRNA in gastric mucosa were significantly higher than those in control subjects. HGF mRNA levels in patients with H. pylori infection were correlated with the severity of gastric mucosal inflammation. Our observations indicate that H. pylori infection increases the expression of HGF gene in gastric mucosa probably through the mucosal inflammation.
幽门螺杆菌（H. pylori）可诱导胃黏膜过度增殖。本研究旨在阐明幽门螺杆菌感染是否参与肝细胞生长因子（HGF）的基因表达，HGF是胃黏膜中一种强大的细胞增殖刺激因子。通过逆转录聚合酶链反应测定了9名对照受试者和9名幽门螺杆菌感染患者的内镜胃活检标本中HGF mRNA的水平。在幽门螺杆菌感染患者中，胃黏膜中HGF mRNA的水平显著高于对照受试者。幽门螺杆菌感染患者的HGF mRNA水平与胃黏膜炎症的严重程度相关。我们的观察结果表明，幽门螺杆菌感染可能通过黏膜炎症增加胃黏膜中HGF基因的表达。
